Animal Models and Experimentation — DU B. Sc. Life Science (Zoology) Previous Year Question Papers

6. (a) Describe the responsibilities, composition and ch.allenges o'f Institutional Animal Ethics Committee. What are the main criteria they use to evaluate and approve an animal research protocol? (9) (b) Distinguish between acute and chronic toxicity studies in preclinical drug testing. (6) 7. Write short notes on any three of the following : (a) Zebra fish as an animal model (b) Anxiety tests (c) Tissue collection and proces.sing (d) Significance of animals in biomedical research (e) Principles of the 3Rs (a) Define any five of the fol.lowing : (i) Isogenic model (iii) Bias (iv) Preclinical trial (b) Distinguish between the'following (any four) : (8) (i) Inbred and outbred animal models (ii) Rat and mice (iv) Hypothesis and objectives (v) Animal we.1fare and animal rights (c) Expand the following terms (any four) : (i) ADME 2. (a) Explain the animal models that are used for studying neurological disorders and discuss their applications. (9) (b) What ethic.al guidelines must be followed when conducting animal experiments? (6) (a) Explain randomization and sample size estimation in the research studies for using animal models. (b) Give details of the regulatory framework prevalent in India with regards to animal research. (6) (a) Define Gene editing. Describe the use of CRISPR- Cas9 technology in creating knockout animal models. (9) (b) What are `Good Laboratory Practices' for animal studies? (6) (a) Are there any alternatives to animal studies? Elaborate on any two of the models, giving their advantages and limitations. (9) (b) Describe the chemical induction of Type I & Type