Pharmacology and Toxicology — DU B.Sc. (Hons) Biological Sciences Previous Year Question Papers

Q3. Differentiate between i. Affinity and Avidity ii. Agonist and antagonists iii. Loop diuretics and thiazides iv. Pharmacokinetics and pharmacodynamics. B. Explain the rule of five that covers effective absorption and distribution of a drug. C. Name the different stages of drug discovery & development. What are the goals and limitations of pre-clinical toxicity studies. D. What is the therapeutic index of a drug. Why is a drug with higher therapeutic index preferred? Q5 A. What is QASR? Elaborate. How does it improve the efficiency in commercial output of a new drug? B. C. How are drugs eliminated from the body? Explain - No nihi graph, in the C of the oraly in ester dis i shove bee lay, is the would be a preferred mode of administration of the drug? Peak effact Therapeutic range phake •-Intensity range. - -- Plasme drug concentration (ug/mL) Absorption fansos of paton. "time Onset (5,5,5) Q6 A Explain the biochemical basis for the action of the following drugs (15) i. Cemitidine ii. PPAR alpha inhibitors iii. Digitalis iv. Anti-epileptic drugs v. Ibuprofen