Bioinorganic Chemistry — DU B.Sc (hons) Chemistry Previous Year Question Papers

2. Attempt four questions in all. 1. (a) What is the role of iron-sulphur [Fe-S] clusters in biological systems? (b) What do you mean by the I & R form of haemoglobin? (c) What is the active metal in carboxypeptidase? Give the coordination number? (d) What is the role of ceruloplasmin in iron transport in the human body? (e) What is the oxidation state of iron in haemoglobin and myoglobin? Is iron low or high-spin in deoxy-haemoglobin? (g) What is Methaemoglobin? (h) How many oxygen molecules are earned by one haemoglobin molecule? 2. (a) Write the toxic effects of Hg (II). Give the reasons for its toxicity? How can it be treated? (b) Classify metal ions according to their action in the biological system. (c) Explain the biological significance of transferrin and ferritin? (d) What are metalloenzymes? Give their significance. (a) Explain the oxygen saturation curves of haemoglobin and myoglobin and their physiological implications. (b) Discuss the role of sodium and potassium ions present in the biological system. (c) Differentiate between trace elements and essential elements in biological systems. (d) What is the biological role of Zn2t? (5,4,3,3) 4. (a) Discuss the role of haemoglobin and myoglobin in transporting O, from lungs to tissues and CO, from tissues to lungs. (b) Write the toxic effects of lead. Give the reasons for its toxicity. How can it be treated? (d) Explain the Bohr effect and its impact on oxygen delivery. (5,4,3,3) 5. (a) Describe the active transport with reference to the sodium-potassium pump. Illustrate the working of the pump with a suitable diagram. (b) Justify, "cooperativity enables haemoglobin to bind and release O2 more effectively." (c) Discuss the role of calcium in the formation of bone. (d) What is the significance of the globin part in haemoglobin? (5,4,3,3) 6. (a) What is porphyrin? Draw and explain the structure of haemoglobin. (b) What happens when carbon monoxide replaces dioxygen in haemoglobin? (c) Mention any two biological functions of potassium and magnesium.