Biostatistics and Bioinformatics — DU B.Sc. (Prog.) Applied Life Sciences with Agrochemicals and Pest Management pertaining to Zoology Previous Year Question Papers

: DSE Biostatistics and 3. Statistical tables should be provided. 4. Attempt four questions in all, including Question No 1. (A) Expand the following abbreviations: (6) (v) ORF (vi) PIR (b) Explain the following symbols : (3) (c) Define the following : (7) (ii) Standard Deviation (iii) Coefficient of Variance (V) Composite database (vii) Gap penalty (d) Differentiate between the following (Any Four): (i) Type I error and Type Il error. (ii) Level of significance and Level of confidence. (ill) Primary Databases and Secondary (iv) Sequence similarity and Sequence homology. (V) bits score and e-value. 2. (a) Ovary weight of 50 fishes and their frequency is given in class interval. Calculate the mean and standard deviation of the given data: Weight of Ovary 3-3.9 4-4.9 5-5.9 6-6.9 7-7.9 (b) What is standard deviation. Discuss about its formula and significance of calculating standard deviation. (8+4=12) 3. (a) Define Chi-square (x') test. Write down the formula of chi-square test and describe the null and alternate hypothesis. (b) The weights (in gm) of a fish, collected from two different ponds were measured as : Conduct t-Test and find out if there is a statistical difference in body weights of the fishes collected from two ponds. (4+8=12) 4. (a) Distinguish between pairwise and multiple sequence alignment. (2+6+4=12) (b) Discuss about Dynamic programming method of pairwise sequence alignment. (c) Discuss about PAM and BLOSUM scoring matrices. 5. (a) Discuss about the role of Bioinformatics in various branches of biology. (b) What is BLAST? Discuss about different types of standard BLAST. (6+6=12) 6. Write short notes on (any three): (4x3=12) (1) Role of Biostatistics in Biological Sciences (lil) Protein Data Bank (PDB)