Molecular Basis of Non Communicable Diseases — DU B. Sc. (Hons) Biochemistry Previous Year Question Papers

There are 6 questions. Attempt four questions in all. (a) Write full forms of the following (any five) : (b) State True/False for the given statements : (i) PCOS is an example of multifactorial disorder. (ii) Emphysema is an acute ovarian disorder. (iii) Atherosclerosis involves deposition of lipids in myocardium (iv) Misfolded proteins are degraded by the proteasome system. 10) Cystic Fibrosis is caused by mutation in CFTR gene. (c) Compare and contrast anorexia nervosa and bulimia nervosa. 5,5,5 (a) Write a short note on molecular basis of cancer and explain the molecular approaches to treat cervical cancer and preventive vaccines. (b) Explain the causes and molecular basis of COPD and emphysema. (c) Discuss the pathophysiology and risk factors associated with 3. (a) Discuss the causes and consequences of Atherosclerosis. (b) Differentiate between Anorexia nervosa and Bulimia. (c) Discuss the biochemistry behind IBS and the role of diet in this condition. 5,5,5 4. (a) Write down the etiology and the molecular basis behind Thalassemia. (b) How does a proteasome system play role in the removal of misfolded proteins ? Explain with diagram. (c) Discuss the molecular basis of Alzheimer's disease. 5,5,5 Write short notes on the following (any five) : (a) Ischemic heart disease (e) Long QT syndrome (f) Maple syrup urine disease. 3×5 (a) What do you understand by metabolic syndrome ? (b) How metabolic syndrome is linked to hypothyroidism and hypertension? (c) Explain the role of diet, stress and environmental factors on metabolic disorders. 5,5,5