Toxicology — DU B. Sc. (Hons) Biomedical Previous Year Question Papers

Attempt five questions in all. Subparts of the questions should be attempted together. Q3 A. Provide the effects of mercury on aquatic ecosystems. Explain the movement of toxicants in the food chain and resulting human toxicity. 5 marks B. Discuss various types of dose response relationships. Discuss the significance of dose response curves in toxicology. 7 marks C. The process of distribution can affect the toxicity of a toxicant. Discuss with suitable example. 3 marks Q4. A. How does the polarity of toxicants affect their excretion? Discuss with suitable examples. 5 marks B. Oxidation biotransformation reactions sometimes can generate reactive metabolite of toxicants. Explain with two suitable examples. 5 marks C. Provide various situations of exposure to lead and its toxicokinetics. 5 marks Q5. A. Discuss roles of following enzyme cofactors in toxicology with one suitable example. i. Heme 3 X 4=12 marks ii. Glutathione iii. S-Adenosyl Methionine B. Discuss various factors affecting absorption of toxicants from lungs. 3 marks Q6. Short notes: 3 X 5-15 marks i. Various sub-disciplines of toxicology and their scopes ii. Physical examination of poisoned patient ill. Main routes of toxic exposure with examples