Applications of Informatics in Biology — DU B. Sc. (Hons) Microbiology Previous Year Question Papers

1. Define the following (any six) : 2x6=12 (il) Accession number (iti) Systems. Biology (io) Functional genomics (vi) Molecular docking (vii) Phylogeny (viii) Annotation. 2. (a) Expand the following (any four) : 1x4=4 (b) Name one database/tool for the following (any four) : 1x4=4 (i) Chemical database (ti) Protein Structure (üi) Allergen Prediction (io) Nucleotide sequences (v) Multiple sequence alignment. (c) Discuss the role of AI (or) Machine learning in disease management. 4 3. Differentiate between the following (any three) : 4x3=12 (i) Local sequence alignment and Global sequence alignment (iv) Rigid and Flexible Docking. 4. Write short notes on the following (any three) : 4x3=12 (i) Human Genome (iii) Gene ontology (iv) Ramachandran Plot. 5. (a) Describe the steps involved in Homology modelling. Name any one tool for homology modelling. (6) What are energy minimizations ? 2 (e) Give a brief account of molecular dynamics simulations. 6. (a) What is CADD ? List the steps in structure-based drug design. (6) What is the significance of BLAST? Name any four types of BLAST. 4 (c) Align the following two sequences, if the Match score (+3), Mismatch score (-1) Gap penalty (4). 3