Chem-DSE-18: Nanomedicine and Nanosensing — DU B. Sc. Life Science (Chemistry) Previous Year Question Papers

(i) What properties of iron-oxide NPs make them useful in imaging? (7.5) (ii) Critically evaluate the advantages and limitations of hybrid organic-inorganic nanomaterials for combined imaging and drug delivery. (7.5) (i) Write down the synthesis of gold nanoparticles and their applications in biological systems. (ii) Write down any synthesis method of silica nanoparticles and their applications. (7.5) (i) How do coumarin dyes contribute to nanomaterial-based drug delivery systems? (7.5) (ii) Discuss how the physicochemical properties of nanomaterials influence their interaction with living systems. (7.5) (i) Explain the basic principles of optical imaging, MRI, CT imaging, and radio imaging in What is chemosensing? Give one example of a chemosensor material. Name one optical sensing technique used with nanoparticles. Define gas sensing and list two common transduction mechanisms. Give two biomedical fluids used in in-vitro diagnostics and one analyte commonly measured in each. (i) Describe optical (plasmonic) sensing using gold nanospheres and nanorods. Discuss localized surface plasmon resonance (LSPR) shifts and factors affecting sensitivity. (7.5) (i) Write down the difference between Phagocytosis and pinocytosis. (7.5)