Biostatistics & Bioinformatics for Plant Sciences — DU B.Sc. (Hons.) Botany Previous Year Question Papers

Semester III 2. Attempt Part A and Part B on separate answer sheets. 1. (a) Expand the following (any five) 5X1=5 (b.) Define (any five) 5X1=5 i. Similarity ii. Query iii. Outgroup iv. Identity v. Homology vi. Cheminformatics 2. Differentiate between the following (any two 2X5=10 1. Gap and penalty ii. BLASTx and BLASTn iii. PDP and PlantPepDB 3. Write short notes on following (any two 2×5=10 i. Aims and scope of Bioinformatics ii. Composite databases iii. Applications of bioinformatics in crop improvement 5 4. (a) What is Molecular Phylogeny? Write the features of a phylogenetic tree. (b) Discuss the salient features of UniProt. 5 1. (a) Define the following (any five): 1x5=5 i. Tabulation ii. Degrees of freedom iii. Variable iv. Histogram v. Mean deviation vi. Central value (b) Match the following: 1x5=5 Column A Column B 1. Population Mean ii. Summation ill. Standard Deviation iv Coefficient of correlation Chi-square 2. Differentiate between the following (any 2) 2x5=10 i. Paired and unpaired t test ii. Positive and negative correlation iii. Type I and type Il error 3. a) Define sampling. What are the various sampling methods used in biostatistics. b) Define chi-square test. Explain goodness of fit with the help of a suitable example. 5 4. a) Name the measure of dispersion that is most widely used and is considered a standard measure Write the formula for the above measure of dispersion. of dispersion? Justify your answer. b) Calculate the coefficient of variance from the following data obtained on the culm length (in 5 cm) of 2 rice varieties. 4. All parts of a question should be answered together. 5. Draw diagrams wherever required. 1. (a) State whether the following statements are true or false (any five): (1x5=5) (i) The term "epigenome" refers to the total set of genes in an organism. (ii) Cas9 endonuclease introduces double-stranded breaks in target DNA. (iii) X-ray crystallography is used to study the tertiary structure of DNA. (iv) PubMed database provides information on metabolic pathways. (v) DNA methylation is a reversible epigenetic modification. (vi) Entrez is a search system for accessing multiple biological databases. (b) Expand the following (any five) : (1x5=5) (c) Fill in the blanks (any five): (1x5=5) (i) A ...... is any maximal consecutive run of spaces in a single sequence in a given alignment. (ii) is the study of the individuality of cells using omics approaches. (iii) CRISPR-Cas9 is derived from the natural immune system of .. (iv) The nucleotide sequence database maintained by NCBI is known as. .. (V) In Edman sequencing, amino acids are removed sequentially from the terminus. (vi) .. is used to determine the 3D structure of proteins using diffraction patterns. 2. (a) Explain the complexity of the eukaryotic genome. Discuss the role of genomics in health. (8) (b) Define molecular phylogeny. With the help of a labelled diagram, explain the different parts of a phylogenetic tree. (7)