Fundamentals of Medicinal Chemistry — DU B.Sc (hons) Chemistry Previous Year Question Papers

DSE-Fundamentals of Medicinal Chemistry 1. (i) Define the half-life of a drug. (ii) Explain the significance of in silico screening. (iii) What are pre-clinical trials of a drug? (iv) Explain the importance of the hydrophilic -hydrophobic balance in drugs. (v) Define and explain prodrugs with suitabl.e examples. 2. (i) Define drug ta`rgets and explain any one method of target identification. (ii) Describe the stages of drug discovery briefly. (iii) What is the difference in metabolic and chemical stabi.1ity of the drug? 3. (i) Define partition coefficient. How is it determined? (ii) Describe Phase 11 metabolism and i`ts major reactions. (iii) Write a short not.e on applications of bioinformatics in medicinal chemistry. (5 x 3 ) 4. (i) Explain the relationship between drug structure and biological activity? (ii) Differentiate between phase 11 and phase Ill clinical trials. (iii) How is drug toxicity evaluated? 5. Short notes on the following (Any three) : (i) Drug Response curve. (ii) Computational tools in drug designing. (iii) Lead optimization. (iv) Natural sources of drugs. 6. (i) Write the structure, describe synthesis and uses of penicillin v. (ii) Discuss the structure and therapeutic value of fluconazole. (iii) Explain antiviral drugs and discuss the SAR of AZT.