Fundamentals of Natural Products — DU B.Sc (hons) Chemistry Previous Year Question Papers

FUNDAMENTALS OF NATURAL PRODUCTS All questions have equal marks. 1. (i) Discuss the scope and modem relevance of natural product chemistry in drug discovery with suitable examples. (ii) Explain primary and secondary metabolites with relevant examples. (iii) Describe Shikimic acid pathway in detail. (5,5,5) 2. (i) Explain isoprene rule with,suitable examples. I.(ii) Discuss the synthesis of LSD. (iii) Explain the principle and working of steam distillation in detail with diagram. 3. (i) What are alkaloids? Discuss its classification. (ii) Explain biosynthesis of Berberine and discuss its importance. (iii) What is the importance ofGC-Ms in natural product analysis?` (5,5,5) 4. (i) Define steroids? Discuss its biological functions. (ii) Give the structure o`f artemisinin and explain its pharmacological importance? (iii) Explain in detail any two chromatography techniques used in natural product analysis. (b) Phenolic compounds (c) Applications of Natural products in medicine 6. (i) Give the structures of two terpenoids which follows isoprene rule. (ii) Give the full form and structure of IPP and DMAPP. (iii) Discuss the sources of natural products in details.