Principles of Immunology — DU B.Sc. (Hons.) Zoology Previous Year Question Papers

3. Attempt FOUR questions in all. 4. Draw neat labelled diagrams wherever necessary. 1. (a) Define the following terms : (1x4=4) (11l) Arthus reaction (b) Differentiate between any THREE of the following : (i) Active immunity and Passive immunity. (ii) Class I MHC molecule and Class II MHC molecule. (iii) Classical pathway and Alternative pathway of the Complement System. (iv) Primary immunodeficiency and Secondary immunodeficiency. (c) Expand the following : (4x0.5=2) (d) Write the contribution(s) of : (3x1=3) (1) Edward Jenner (ii) Wu and Kabat (iii) Milstein and Köhler 2. (a) Describe in detail the role of various barriers involved in the innate immune system. (b) Define Immunogenicity. Discuss the factors influencing immunogenicity. 3. (a) Elucidate the structure of the antibody based on experiments. (8) (b) Explain the processing and presentation of endogenous antigens in a cytosolic pathway. (7) (a) Categorize the hypersensitivity reactions as per Gell and Coombs classification. Elaborate on Type 1 and Type II Hypersensitivity reactions in detail. (b) Illustrate and discuss the production and selection of monoclonal antibodies by hybridoma technology. (7) (a) Describe the various types of vaccines. How is a multivalent vaccine better than a monovalent (b) Define autoimmunity and describe its probable (7) Write short notes on any THREE of the following: (i) Clonal Selection Theory (iv) Lectin pathway of the complement system (v) Cardinal signs of inflammation