Developmental Biology — DU B. Sc. (Hons) Biochemistry Previous Year Question Papers

Semester VII CREDIT DISTRIBUTION, ELIGIBILITY AND PRE-REQUISITES OF THE COURSE Course Credits Credit distribution of the course Eligibility Pre-requisite of title & Lecture Tutorial Practical/ criteria the course Code Practice (if any) Developme 4 2L 2P Class XII -n tal with Biology Science Learning Objectives Learning Outcomes On successful completion of the course, students will: Students will acquire knowledge about basic concepts of developmental processes, fertilization, germ layer formation and patterning of body plan. Students will gain detailed insight into the molecular events of embryogenesis, importance of various model systems and their applications in understanding human development and associated defects. Students will learn about Stem cells, their roles in development and significance in development of regenerative medicines, current applications and advancement in stem cell research. SYLLABUS OF DSE-11 BCH-DSE-11: DEVELOPMENTAL BIOLOGY Semester - VII Credits: 2 Total Hours: UNIT 1: Introduction to Developmental Biology No of hours: History, Evolutionary embryology and Basic concepts of developmental biology, Overview of fertilization, early development- Patterns of cleavage, germ layer formation, implantation, placentation, Formation of blastula, embryogenesis: Nieuwkoop center, Spemann-Magold formin theory and mesodermal induction, Gastulation, Fate maps, and neural tube UNIT 2: Molecular biology of development No of hours: Role of differential gene expression in development, Role of cell-cell communication in development. Key signaling pathways in development: Fgf, Hedgehog, Wnt, TGFß, and Notch. Cadherins in establishing intercellular connections, Role of extracellular matrix in development Concepts of induction and competence and senescence. UNIT 3: Study on model organisms No. of hours: Caenorhabditis elegans: Study of cell lineage, mosaic development and organogenesis (vulva formation). Drosophila melanogaster: Role of maternal effect genes, morphogens and zygotic genes (Gap genes to homeotic genes) in axis formation and body patterning. Danio rerio (Zebra fish): Study various early embryogenesis stages starting from the zygote -cleavage - blastula - gastrula - segmentation, pharyngula, hatching and early larval development. Study mechanisms of pigmentation and stripe patterning in fish skin. UNIT 4: Stem cells and their implications in treatment strategies: No of hours: Stem cells and their types, Pluripotent cells, Induced pluripotent stem cells and their applications in human development and diseases. Ethical issues. UNIT 5: Developmental defects and the role of teratogens: No. of hours: Chemical, physical and biological agents which can cause developmental defects. Brief discussion of alcohol and retinoic acid as teratogenic agents. Credit: 2 Total Hours: 1. Study of life cycle and developmental stages of Zebrafish.