Advances in Immunology — DU B. Sc. (Hons) Microbiology Previous Year Question Papers

1. Explain the following (any 6) : (i) Surrogate light chain (2i) Immunoprivileged sites (iii) National Immunization Schedule (io) Tumor specific antigens (vi) Self MHC restriction (vil) Co-stimulatory signals (vili) VDJ Recombination. 2. (a). Differentiate between the following (any 3) : (i) Type III and IV Hypersensitivity (ii) Naive and Memory cells (iii) Primary and Secondary immune response (io) Active and Passive immunisation. (b.) Discuss various evasion mechanisms adopted by cancer cells to escape immune surveillance.. - 3. Write short notes on the following (any 3) : (i) Anticancer therapy Generation of Humoral immune response (ju) Killing mechanisms of N cells. Give salient features of the following diseases (any 4) : 3×4=12 (i) Haemolytic anaemia (it) Goodpasture syndrome (io) DiGeorge syndrome . * (0) Multiple sclerosis. (b) Give the technical term or one word for the following (any 6) : 1x6=6 (i) An abnormal immune response against self-antigens (i) Organ transplant from identical twin (iii) First heavy chain to appear after gene rearrangement The dead microorganism which is a component of Freund's complete adjuvant (0) Type of vaccine involving a surface protein of a pathogen (vi) Allergic condition affecting nasal mucosa (vi) An immunodiagnostic using fluorescent probes. (viii) When I cells can perceive antigens presented only by own Why do some vaccines require boosters ? 4 (b) Discuss various mechanisms which transform normal cells into cancer cells. (e) Describe various immunosuppressive therapies used to enhance the survival of grafts. (a) Expand the following abbreviations : (b) What is chronic graft rejection? How is it different from acute. and hyperacute rejection ? (e) Briefly describe the mechanism of Type I hypersensitivity.