Human Pathology — DU B. Sc. (Hons) Biomedical Previous Year Question Papers

Attempt five questions in all. Subparts of the questions should be attempted together. Draw illustrations or diagrams wherever necessary. 1. (a) Differentiate between 2x4=8 Pseudocyst and True cyst (ii) Serous and Fibrinous inflammation (ii) Haemorrhage and Hematoria (b) Define : Elines set Parat arians 2x5=10 (c) S,tate True/False and justify (any foz47.) :. (Z) Envirqumental factors, such as smoking, can lead to bronghial dysplasia. (a.i) Neutrdyhils are often the first cells to arrive at the site of acute inflammation. Gz.i) .Le.ft-sided heart failure .cause pulmonary edema. (a.u) Bone remodelling differs in child and adult. 2. Write short notes on : \ 6,5,5 G) Role of AA metabolites in inflammation (I.i) Stages of shock (cb) A 60-year old woman developed chest \pain. that pers'isted for 4 hours. A radiographic imaging pl.ocedure showed an apparent myocardial infarction involving a 3 x 4 .cm area of the posterior left ventricular free wall; Lad)oratory. findings showed serum creatine kinase of 600 UEL. What changes must ha.ve taken place ,in the myocardium of' the w`oman ? What change would be observed in the tissue after 2 months of this myocardial infarction ? (b) Discuss the risk factors, pathogenesis, morphology and complications of (c) Give any one physiological and pathological reason of the following : (e) Draw well labelled schematic for : 6 Antithrombotic properties of endothelium (ii) Intracellular destruction of microbes by ROS and NO. (a) The journey of neutrophil from the vessel lumen to the site of inflammation is .a multistep process, meant to take care of acute inflammation. Explain in detail. Comment on the statement that inflammation is a double edge sword. 5. (a) What are extracellular`matrix components? Disctiss their role in wound h eating. 5 (c) Mr. Gulati, age 48 .years, has had a persistent unproductive cough for several months that did not respond to cough medications. Recently, he has developed a productive cough accompanied by fatigue, anorexia, an`d night sweats. Examination indicated abnormal chest sounds and weight loss.T A chest radiograph showed a small cavity and, infiltrate, the tuberculin test wa.s positive~, and the sprrfum sampJle contained a small amount of blood and numerous a'ci.d-fast baciITi. What could be your diagnosis? Discuss its pathogenesis.. , 6. 6. (a}) Give one word for the following : 5 (i) A sample of tissue or fluid taken for examination from a human body (I.i) Determination of the nature of disease (a.I.i) Traumatic injury to the slin or tissues beneath the skin (c) What is the difference between arteriosclerosis arid atherosclerosis ? Discuss the pathogenesis of atherosclerosis. 6