Immunobiology — DU B. Sc. (Hons) Biomedical Previous Year Question Papers

ro) Discuss clonal selection theory in detail. IgM and I.gD are coexpressed on the same a cell. Does this violate the unispecificity O,,®,O,a,,,® ,,,,,,,,, rule as implied by clonal selection theory? 6.. .(a). Describe with the help of diagram (Any two): 6+6=12 (i) Neutrophil extravasation. : B.Sc® (Hone.) Biomedi-cal Science (NEP- (iii) TS of Thymus. What is hypersensitivity? Discuss the role of lgE in inducing hypersensitive reaction. TTme : 8 Hours (c) Give illustrations and examples wherever required. (d) Subparts of the questions should be attempted together. 1. (a) Briefly explain the following (Any four): (iii) Macrophage (b) Differentiate between (Any two): 4x2=8 (ii) a-cell epitope and T-cell epitope (iii) Cellular immunity and humoral immunity 2. (a) What is haematopoiesis? Discuss the pathway in detail .involving lymphoid and myeloid lineages. 6 (b) What is ADCC? Discuss the process in detail and explain how does it kill the target cell? 6 (c) Complement is a set of serum proteins which help the immune system to eliminate pathogens. Discuss how classical pathway of complement activation is initiated by antigen-antibody complex formation. 6 3. (a) Explain the und.erlying principle of the any two methods: 6+6=12 4. (i) Western blotting (iii) Agglutination (b) Discuss the characteristics features of recombinant vaccine with an example. 6 (a) What are haptens? How can they be made immunogenic? Discuss with an examp'1e and its clinical signiricance. 6 (b) The endogenous antigens are processed in the cytosolic pathway. Discuss how does this pathway eliminate and present endogenous antigens on the membrane with class 1 MHc molecules? 6 (c) What are immunotoxins? How can they be used in the treatment of cancer? 6 5. (a) Humoral and cell mediated branch of the immune system work in collaboration to mount an effective and robust immune response. Describe in detail with the help of diagrams? 10