Pharmacology — DU B. Sc. (Hons) Biomedical Previous Year Question Papers

5. (a) Explain giving the mechanism of action of dopamine how carbidopa can be used to potentiate its action. (b) What are sympathomimetic drugs? Discuss 5 (c) What is dose response curve? Explain how it can be used to differentiate between a competitive and nor competitive antagonist, 6. (a) How does half-life influence the dosing interval of a drugs? (b) Explain the factors on which depth of ariaesthesia depends for inhalational anaesthetic agents. 5 (c) Discuss the classification of antimicrobial agents. What are the problems associated with the use of various antimicrobial agents? 5 Science (NEP-UGCF) (c) Subparts of the questions should be attempted together. 1. (a) Define (Any Five) 5×2=10 (i) Drug Clearance . .._ — (ii) Steady State Plasma Concentration (iii) Blood Brain Barrier (iv) Non-Proprietary Name (b) Di`scuss the different mechanisms through which drug is able to cross the biological (v) Therapeutic window membrane. Discuss how the pKa of the (vi) Cholinomimetic drugs drug and pH of the medium influence this (b) Differentiate (Any three) (i) Placebo and Nocebo process. (ii) Enteral and Parenteral route of drug administration 3. (a) Differentiate between the different types of metabolic enzyme that are involved in (iii) Bioequivalent and Therapeutically equivalent drugs metabolism of drugs. What is enzyme induction? What will be the consequence (iv) Pharmacodynamics and pharmaco]chetics of this irlduction for any drug? 8 (c) State true and false andJustify. 4x2=8 (i) Overuse of narrow spectrum antibiotics leads to development of superinfection (b) What are oral hypoglycemic agents? Discuss the classification and the mechanism of action for each class. 7 (ii) The greater the extent of plasma protein binding of a drug, higher its (iii) Aspirin can be used for patients with Give the mechanism of aption of the following drugs along with their clinical uses. (Any tbree) 5+5+5= 15 peptic ulcers. (a.) Succinyl Choline (vi) Changes in urinary pH does not affect the tubular reabsorption of drugs. 2. (a) What is volume of distribution? What are (c) Progestrone the factors on which volume of distribution dep ends? 8