Pathological Basis of Disease — DU B. Sc. (Hons) Biomedical Previous Year Question Papers

4. Subparts of the questions should be attempted together. 5. Draw illustrations or diagrams wherever necessary. A. Define: (Any four) ii. Karyorrhexis ili. Anaplasia iv. Biopsy B. Justify / Explain the following (Any four) (2.5X4=10) ii. ESR is an indicator of inflammation. Inflammation is considered as a protective response of body. Shock is circulatory failure. umors are said to be clona hrombus develops frequently after surger • C. Differentiate between Acute and Chronic inflammatic (3X4=12) Stable and Labile Tissue iii. Reversible and irreversible injur iv. Benign and Malignant neoplast Q2. Write short notes, Hallmarks of cancer (5,5,5) Probable fate of a thrombus Role of extra cellular matrix in wound healing (a) Write a detailed note on the importance of molecular diagnostic techniques in medicine (b) What do you understand by cellular adaptations? Give a note on physiological and with reference to PCR based assays. pathological conditions leading to hypertrophy and atrophy. (a) Regeneration of the liver is a classic example of repair by regeneration. Taking the liver as an example, elaborate upon the mechanism of tissue regeneration. (b) What do you mean by oncogenes? What role do they play in tumor initiation and progression? (a) Define necrosis. Describe the different morphological patterns of necrosis with examples Q5. (8) nd morphological features' (7) b) Discuss various immunological assays for detection of disease (a) Chronic inflammation is characterized by leucocyte infiltration, tissue damage and fibrosis. In the light of the given statement, elaborate upon the role of several cell types and molecular mediators involved in the process. (b) Give a well labelled schematic for i. Healing by second intention il. Leukocyte recruitment