Pharmacological Science — DU B. Sc. (Hons) Biomedical Previous Year Question Papers

2. Attempt five questions in all 4. Attempt subparts of a question together. Q1. (a) Define (Any Six) Orphan drugs ii. Proprietary Name iii. Bio-transformation iv. Half-life of drug V. Pharmacodynamic vi. Pre-systemic metabolism vii. Agonist (b) Differentiate between (Any Three) (3x4=12) Efficacy and Potency iv. Zero order and First order kinetics (c) State True or False. Justify your answer. (Any Two) . (2x3=6) Brand names help in identifying the chemical composition of drugs Inly free (unbound) drug is pharmacologically active Drugs given via enteral routes can be affected by gastric pH and food. Q2. Write mechanism of action and contraindications of (Any Three) Q3. Write short note on • Q4. (a) Discuss the classification of drug dosage forms according to their physical state. Give two examples from each category and mention a key point about their use or formulation. (b) Explain the determinants for selecting a route of drug administration. Give the advantages and disadvantages of oral administration. (c) Describe the relationship between urine pH and renal excretion of drugs. How does this affect acidic and basic drugs differently? Give examples. (5,5,5) Q5. (a) Explain the major classes of macromolecular targets of drugs and their significance in pharmacology. (c) Discuss the significance of graded versus quantal dose-response curves in pharmacology, emphasizing the distinction between individual and population- level responses. Q6. (a) Describe antimicrobial therapy and discuss how bactericidal drugs differ from bacteriostatic drugs in their action. (b) Explain the different phases of drug metabolism and their significance in pharmacology. (0) Define adverse drug reaction (ADR) and discuss how pharmacovigilance helps in (5,5,5) detecting, preventing, and managing ADRs.