Immune Response to Infection and Diseases — DU B. Sc. (Hons) Biomedical Previous Year Question Papers

Type of Paper Discipline Specific Elective (DSE) *. Attempt five questions, in 'all: Give illustrations and examples Wherever required "Subparts of the quěstions should be attempted together. (a) Assertion, and Reason (any three) : = 7 (A) Both A änd R are true and R' is the correct explanation; (B) Both A 'and R are true but R' is not the correct explanation; (C) À is true, , R is false; 1 3) (D) A is false, R is true = 1x jean, was "Assertion : yộ I cells can recognize antigens without MHC presentation. . Reason : yo TCRs can recognise sugars on certain microbes. (ti) Assertion : Allelic exclusion ensures that each T-cell, expresses, a single type of TCR. Reason : Both alleles of TCR genes are rearranged simultenously » to increase diversity. ur°. (iii) Assertion : NK cells can kill virus-infected cells without prior sensitization. cason : They recognize cells with decreased or absent MiHic alass li) Assertion : Epinephrine iş used to treat, anaphylactic reactions Reason: It blocks IgE, production by B-cells. (6) Hypothetical Problems (any three) (i) A 15-year-old, boy develops wheezing, and swelling within minutes of "exposing to dust and pollen grains. Which antibody and effector cells are responsible i (iż) A newborn develops hemolytic disease due to Rh incompatibility. Which antibody, mediates red blood cell destruction! iü) A Serum sickness occurs after administration of foreign antiserum. What immune mechanism causes tissue damage in this condition ? (iv) Class switching in B-cells changes the antibody isotype. Give one consequence of class switching on immune function. (a) Differentiate between tumor-specific antigens and tumor-associated antigens. (b) Explain one example of monoclonal antibody therapy used in cancer immunotherapy. 6,6. 3. (a) Explain the various strategies employed by viruses to evade the host immune response.. (b) Illustrate how failure of central and peripheral tolerance contributes to (6) Describe the immune response against Mycobacterium tuberculosis. How does this immune response lead to the formation of granulomas in the infected tissue ? 6,6 (b) Describe the mechanism of any one organ specific autoimmune disease. (a) Explain the mechanism of Delayed-Type hypersensitivity and name at least two diseases in which this type of hypersensitivy plays a major role. , (6) Discuss the interplay between innate and adaptive immune responses in the recognition, activation and elimination of pathogenic microorganisms. Tri= = •Io 170g gnsa 1015% ufe i sd ad spet' sarte las, in"a Be l" el? narsar see ret -t