Model Organisms in Biomedical Research — DU B. Sc. (Hons) Biomedical Previous Year Question Papers

(b) A researcher exposes zebra fish embryos to a chemical pollutant and observes developmental defects. Explain how this experiment helps in ecotoxicology. (6,6) 5. Discuss the following : (any. three) (3x.4=12) (i) Ethical issues in using model organisins (ii.) Application ctf C. e/egcz#s in ageing (iii) Dz.ctyosje/i.c/in as a model organism (iv) Role of vertebrate models. in biomedical research Biomedical Research Science OrEP) 2. Attempt four questions in all. 4. Subparts of the questions should be attempted together. 5. Give illustrations and examples wherever required. 1. (a) State True/False and give reason for your answer (i) Rats are genetically identical in all laboratory strains. (ii) Genetic screening is difficult in zebra fish due to lack of mutagenesis tools. (iii) Nobel Prize-winning discoveries have been TrLade T]sing Drosophila melanogaster (iv) Rabbits cannot be used for physiological studies. (b) Based on the following experimental scenario, select an appropriate model organism and justify your choice. (4x4=16) (i) A researcher wants to produce a recombinant protein quickly and cheaply with high yield. (ii) A researcher is studying cardiovascular physiology and drug response in a mammalian system requiring repeated sampling. (iii) A researcher needs an easy to maintain eukaryotic system to study cell division and cell cycle checkpoints. (iv) A researcher is investigating genes controlling body patterning and organ development. 2. With the help of well-labelled diagrams, describe the life cycle of the following model organisms. (a) Baker's Yeast (I)) Drosophila melanogaster (6,6) 3. Discuss the advantages and disadvantages of using the following as a model organism :